PolyHeal Micro

APPLICATION

PolyHeal® Micro

APPLICATION

PolyHeal® Micro

PolyHeal® Micro

PolyHeal® Micro is an innovative product based on Negatively-Charged Microsphere (NCM) Technology and is indicated for the treatment of ulcers of different aetiologies and hard-to-heal wounds, including those with exposed bone and tendon without infection.

PolyHeal® Micro is comprised of a suspension of Polystyrene Negatively-Charged Microspheres (NCM) at a concentration of 4.5 x 106 microspheres/ml, suspended in glycerol and water for injection.

The application of PolyHeal® Micro leads the patient’s own cells to reactivate the healing process and accelerating the formation of granulation tissue, favouring wound closure.

Medical device under CE Mark, manufactured under ISO 13485.

BEFORE

THE APPLICATION OF POLYHEAL® MICRO

AFTER

THE APPLICATION OF POLYHEAL® MICRO
Chronic wound without
extracellular matrix

In a chronic wound situation there is an overall decrease in all
components of the extracellular matrix, cells lose their ability to
proliferate and, as a consequence, end up in apoptosis.

Re-establishment of the
extracellular matrix

The NCM provide an additional surface for cell attachment and activation.
This increases the number of cells in the wound bed, re-establishing
the extracellular matrix and therefore reactivating the healing process.

BEFORE

THE APPLICATION OF POLYHEAL® MICRO
Chronic wound without
extracellular matrix

In a chronic wound situation there is an overall decrease in all components of the extracellular matrix, cells lose their ability to proliferate and, as a consequence, end up in apoptosis.

AFTER

THE APPLICATION OF POLYHEAL® MICRO
Re-establishment of the
extracellular matrix

The NCM provide an additional surface for cell attachment and activation. This increases the number of cells in the wound bed, re-establishing the extracellular matrix and therefore reactivating the healing process.

What is Negatively-Charged Microsphere (NCM) Technology?

Negatively-Charged Microsphere Technology refers to the polystyrene microspheres that carry sulfonate groups on their surface, providing a net negative charge. Such charges increase the readiness by which the macromolecules may anchor onto their surface.

INDICATIONS

What are the indications for PolyHeal® Micro?

PolyHeal® Micro is indicated for the treatment of ulcers of different aetiologies and stagnant and hard-to-heal wounds, including those with exposed bones and tendons without infection.

Diabetic foot ulcers, venous and arterial leg ulcers, pressure ulcers;

Acute post-traumatic, post-surgical wounds;

Ulcers in co-morbid patients.

Diabetic foot ulcer
Diabetic foot ulcer
Venous ulcer
Wounds with exposed bones

It is recommended that PolyHeal Micro is applied on wounds with low to moderate level of exudate. The wound bed should always be prepared before the application of PolyHeal® Micro.

Access the following link to view the outcomes obtained with PolyHeal® Micro:

What outcomes can be expected with PolyHeal PolyHeal® Micro?

PolyHeal® Micro reactivates the healing process and accelerates the production of granulation tissue, favouring wound closure. Two outcomes may be expected, depending on patient profile and wound characteristics:

Complete closure by epithelialization.

Formation of granulation tissue. Physicians may choose to continue with the treatment until the wound is closed by secondary intention or skin graft.

Wounds with exposed bones and tendons

EXPOSED BONES AND TENDONS (EB&T)

Treatment with NCM triggers the wound-healing process in exposed wounds with EB&T.1

57% of patients with EB&T wounds treated with NCM achieved ≥75% granulation tissue after 4 weeks.
None of the control group patients reached this granulation tissue percentage.1

References

  1. Shoham Y, et al. Wound ‘dechronification’ with negatively-charged polystyrene microspheres: a double-blind RCT. J Wound Care. 2013 Mar; 22(3):144-55.