The most relevant clinical information about Negatively-Charged Microspheres (NCM) is provided below.
Double-blind, randomized clinical trial (RCT). Patients with hard-to-heal wounds, defined as refractory to treatment for at least 4 weeks, or those with wounds with exposure to bone, tendon, or ligaments, were eligible for inclusion and randomly assigned to the MCN or control group. Both groups were treated (MCN or control) for 4 weeks. Fifty-eight patients completed the study. The primary endpoint was defined as coverage of > 75% of the wound area by light red granulation tissue after 4 weeks of treatment.Read more
Prospective case series of patients with difficult-to-heal diabetic foot ulcers. Daily treatment with MCN was applied for four weeks, although the healthcare professional could decide to continue treatment with MCN in some patients. Cases were followed up to week 12. MCN treatment was completed in 17 ulcers (16 patients). The following parameters were measured: Wollina (granulation tissue, colour and tissue consistency), area and reduction (%) of wound area and complete closure.Read more