PolyHeal® Micro is based on Negatively-Charged Microsphere (NCM) Technology. This technology shows an innovative mechanism of action which is unique among currently available wound-healing products.
One mechanism that fails in wound healing is a persistent activation of the inflammatory phase which fails to progress properly, leading to stagnation.
Cytokines participate in both the inflammatory and the proliferative phase. Controlling the local cytokine balance is essential for promoting wound healing. In this regard, the NCM promote an anti-inflammatory response by influencing selective cytokine production by adherent monocytes and macrophages.3, 4
Following a characterisation of cytokine gene expression in human monocytes treated with NCM, TNFα and IL1ß concentrations were lower in wound fluid treated with NCM than in the control group.4
NCM mimic the functions of the extracellular matrix, providing an additional surface for cell attachment. The attachment of the cells involved in the healing cascade to NCM results in cell activation, proliferation and migration.5, 6
These cells are mainly endothelial cells, fibroblasts and keratinocytes.
Main results of the activation, proliferation and migration of these cells are:
PolyHeal® Micro decreases the concentration of metalloproteinases (MMP) in the wound bed. MMP are enzymes involved in the remodelling of the connective tissue during wound healing. An increased concentration of MMP destroys the components of the extracellular matrix, impairing tissue regeneration.
When the metalloproteinases come into contact with the NCM they can be adsorbed onto their surface. This neutralizes their action because of a decrease in their concentration, reducing the degradation of the extracellular matrix and favouring tissue regeneration.2, 9
In a chronic wound situation there is an overall decrease in
all components of the extracellular matrix, cells lose their ability
to proliferate and, as a consequence, end up in apoptosis.
The NCM provide an additional surface for cell attachment and activation.
This increases the number of cells in the wound bed, re-establishing
the extracellular matrix and therefore reactivating the healing process.
In a chronic wound situation there is an overall decrease in all components of the extracellular matrix, cells lose their ability to proliferate and, as a consequence, end up in apoptosis.
The NCM provide an additional surface for cell attachment and activation. This increases the number of cells in the wound bed, re-establishing the extracellular matrix and therefore reactivating the healing process.
Negatively-charged Microspheres provide an additional surface to which a variety of cells and macromolecules involved in the healing process can attach and interact. This promotes the reactivation of the stagnant healing process.5, 6
Cell attachment to NCM in the wound bed results in morphological and functional cell changes that reactivate healing.7, 8
Electron microscopy image of a myofibroblast attached to a NCM
Biomolecular recreation of cell attachment