NCM’s provide a multi-point contact surface for cellular attachment.3
The Negative Charge in NCM’s surface improves cellular attachment and interaction.5
Acute wounds normally heal in an orderly manner by progressing through four overlapping phases: hemostasis, inflammation, proliferation and remodeling.
Throughout these phases, components of the extracellular matrix play an important role in regulating and integrating many key processes of healing.
Please, see below the main publications about the mechanism of action of PolyHeal® Micro.
1. Correa LG, et al. Negatively charged microspheres provide an additional surface for cell attachment leading to proliferation, tissue regeneration and wound healing (Poster). Presented in European Wound Management Association Congress (EWMA) 2017.
1. Shoham Y, et al. Wound 'dechronification' with negatively-charged polystyrene microspheres: a double-blind RCT. J Wound Care. 2013 Mar; 22(3):144-55.
2. Weissman O, et al. Post-facelift flap necrosis treatment using charged polystyrene microspheres. Can J Plast Surg. 2013; 21(1):45-7.
3. Govrin J, et al. New method for treating hard-to-heal wounds: clinical experience with charged polystyrene microspheres. Wounds UK. 2010; 6(4); 52-61.
4. Carré A, et al. How Substrate Properties Control Cell Adhesion. A Physical–Chemical Approach, Journal of Adhesion Science and Technology. 2010; 24:5, 815-830.
5. Khatua D, et al. Influence of Charge Densities of Randomly Sulfonated Polystyrene Surfaces on Cell Attachment and Proliferation. Journal of Nanoscience and Nanotechnology. 2011; Vol. 11, 4227–4230.
6. Weissman O, et al. Treatment of wounds following breast reduction and mastopexy with subsequent wound dehiscence with charged polystyrene microspheres. Wounds. 2014; 26(2):37-42.
7. Renò F, et al. Adsorption of matrix metalloproteinases onto biomedical polymers: a new aspect in biological acceptance. J Biomater Sci Polym Ed. 2008; 19(1):19-29.
8. Guest JF, et al. Cost-effectiveness of using Polyheal compared with surgery in the management of chronic wounds with exposed bones and/or tendons due to trauma in France, Germany and the UK. Int Wound J. 2015 Feb; 12(1):70-82.